Infectious bovine rhinotrachetis virus mutants, vaccines contain

Details Infectious bovine rhinotrachetis virus mutants, vaccines contain Infectious bovine rhinotrachetis virus mutants, vaccines contain

1990-10-01

1992-07-07

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

4351721, 4351723, 4352351, 4353201, 935 12, 935 32, A61K 39265, A61K 3576, C12N 700, C12N 701

Patent

active

051281295

ABSTRACT:
Infectious bovine rhinotracheitis virus (bovine herpesvirus type 1) mutants containing deletion and/or insertion mutations in a major viral glycoprotein gene, such that no antigenic polypeptides encoded by the viral gene are produced, vaccines for infectious bovine rhinotracheitis containing the same, methods for the production of the same and methods for use of the same. Animals vaccinated with these mutants do not develop antibodies to the viral glycoprotein and can be distinguished serologically from animals infected with infectious bovine rhinotracheitis virus field strains.

REFERENCES:
patent: 4810634 (1989-03-01), Post et al.
Van Drunen Littel-Van den Hurk et al. (1986) J. Virol 59(2), 401-410.
Zuckermann et al. (1990) J. Virol, 64(2), 802-812.
Robbins et al. (1986) J. Virol, 58(2), 339-347.
Robbins et al. (1986) J. Virol, 59(3), 635-645.

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