Infectious bovine rhinotracheitis virus vaccine and method of pr

Details Infectious bovine rhinotracheitis virus vaccine and method of pr Infectious bovine rhinotracheitis virus vaccine and method of pr

1978-02-13

1979-01-02

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

195 13, 424 85, 424 86, A61K 3912

Patent

active

041327756

ABSTRACT:
Pathogenic infectious bovine rhinotracheitis (IBR) virus may be modified by serial passages in non-bovine tissue cultures until it becomes non-pathogenic when applied to the intranasal passages of bovines. Such application will result in the induction of high levels of interferon in nasal secretions as well as the production of local antibodies and a long lasting immunity against IBR infection by virtue of the induction of specific circulating antibodies. The invention includes the method of modifying the IBR virus, a method of preparing a vaccine therefrom and a method of immunizing bovines and promoting production of high levels of interferon in nasal secretions.

REFERENCES:
patent: 3366543 (1968-01-01), Kucera

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