Infection-resistant materials and method of making same through

Details Infection-resistant materials and method of making same through Infection-resistant materials and method of making same through

1984-04-30

1986-04-08

Griffin, Ronald W.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Heart valve

Having rigid or semirigid pivoting occluder

623 11, 623 16, 623 18, 604265, 604285, 128127, 1283355, 424 27, 424 95, 435 1, 514157, A61F 224, A61F 228, A61F 230, A61K 31625

Patent

active

045810281

ABSTRACT:
Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as metal salts of sulfonamides and other antimicrobials or antibacterials, such as piperacillin. In particular illustrative embodiments, silver sulfadiazine is complexed by novel techniques with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during, or after, surgery or implantation of a device.

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