Infection-resistant compositions, medical devices and surfaces a

Details Infection-resistant compositions, medical devices and surfaces a Infection-resistant compositions, medical devices and surfaces a

1988-10-14

1991-05-28

Lusignan, Michael

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

623 11, 623 16, 2167, 427 2, 4273855, 427387, 4274071, 604265, 606151, 523113, 523122, A61F 206

Patent

active

050190962

ABSTRACT:
A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a silver salt and chlorhexidine (or its salts); also disclosed are medical devices having the synergistic composition therein or compositions thereon.

REFERENCES:
patent: 3566874 (1971-03-01), Shepherd et al.
patent: 3674901 (1972-07-01), Shepherd et al.
patent: 3695921 (1972-10-01), Shepherd et al.
patent: 3699956 (1972-10-01), Kitrilakis et al.
patent: 3705938 (1972-12-01), Hyman et al.
patent: 3987797 (1976-02-01), Stephenson
patent: 4024871 (1977-05-01), Stephenson
patent: 4054139 (1977-10-01), Crossley
patent: 4318947 (1982-03-01), Joung
patent: 4381380 (1983-04-01), LeVeen et al.
patent: 4539234 (1985-09-01), Sakamoto et al.
patent: 4563485 (1986-01-01), Fox et al.
patent: 4581028 (1986-04-01), Fox et al.
patent: 4592920 (1986-06-01), Murtfeldt
patent: 4603152 (1986-07-01), Laurin et al.
patent: 4612337 (1986-09-01), Fox et al.
patent: 4675347 (1987-06-01), Mochizuki et al.
patent: 4677143 (1987-06-01), Laurin et al.
patent: 4769013 (1988-09-01), Lorenz et al.
patent: 4853978 (1989-08-01), Stockman
"Silver Treated Graft Materials for Coverage of Infected Burn Wounds", Ch. L. Fox, S. M. Modak, W. Stanford, Ann. Chir. Plast. 1979, vol. XXIV-No. 3, pp. 265-267.
Quensel LB, et al. "Synergism between Chlorhexidine and Sulphadiazine", Appl Bact 45:397-405, 1978.
Inman R. J., et al. "Prospective comparison of Silver Sulfadiazine 1 percent plus Chlorhexidine Digluconate 0.2 percent (Silvazine) and Silver Sulfadiazine 1 percent (Flamazine) as Prophylaxis Against Burn Wound Infection", Burns 11:35-40, 1984.
Snelling F. T., et al. "Comparison of 1 percent Silver Sulfadiazine With and Without 1 Percent Chlorhexidine Digluconate for Topical Antibacterial Effect in the Burnt Infected Rat", J. Burn Cap and Rehab 9(1):35-40, 1988.
"Antimicrobial activity of silicone rubber used in hydrocephalus shunts, after impregnation with antimicrobial substances", R. Bayston, R. D. G. Miller, J. of Clin Path 34: 1057-1062, 1981.
"The sustained release of antimicrobial drugs from bone cement: An appraisal of laboratory investigations and their significance", R. Bayston, R. D. G. Milner, The Journal of Bone and Joint Surgery, vol. 64-B, No. 4, 1982, 460-464.
"Mechanical properties of antibacterial silicone rubber for hydrocephalus shunts", R. Van Noort and R. Bayston, Journal of Biomedical Materials Research, vol. 13, 623-630 (1979).
"Effect antibiotic impregnation on the function of slit valves used to control hydrocephalus", R. Bayston, Z. Kinderchir, Band 31, Heit 4, Dec. 1980, 353-360.
"Controlling drug release from acrylic polymers: in vitro studies with potential oral inserts", I. M. Brook, C. W. I. Douglas and R. Van Noort, Biomaterials, 1986, vol. 7.
"Drug Delivery Systems", 1987 Conference Proceedings.
"Controlled release of polypeptides using injectables or implants", RS Langer, Drug Delivery Stems, 16-17.
"Controlled Delivery of Topical Antibiotics", Presented at the Novel Drug Delivery Technologies Conference, Michael Szycher, Ph.D.
"In vitro studies into the release of chlorohexidine acetate, predisolone sodium phosphate, and prednisolone alcohol from cold cure denture base acrylic", Journal of Biomedical Materials Research, vol. 16, 145-157 (1982) M. Addy and M. Thaw.
"Aids Therapeutics: antivirals and disinfectants", Infections in Medicine, Mar. 1987, 90-109.
"Experimental use of a slow release device employing chlorohexidine gluconate in areas of acute periodontal inflammation", J. Coventry and H. N. Newman, Journal of Clinical Periodontology, 1982, 9, 129-133.
"Mechanical strength of acrylic bone cements impregnated with antibiotics", J. Biomed. mater. res., vol. 10, 837-845, (1976) "Efficacy of a latex foley catheter with sustained release of Chlorohexidine", 1st report, Clinical trails for prevention of urinary tract infection", H. Nakano, S. Seko et al.
"Bone cement and antibiotics", Ger E, D. Dall et al., S. A. Medical Journal, Feb. 1977, 276-279.
"Prevention of catheter sepsis by antibiotic bonding", Trooskin S. Z., A. P. Donetz et al., Surgery, May 1985, 547-551.
"Evaluation of specific systemic antimicrobial therapy in patients while on closed catheter drainage", H. K. Butler and Calvin Kunin, The Journal of Urology, vol. 100, Oct. 1968, 560-566.
"A hydrophilic polymer-coated antimicrobial urethral catheter", J. Biomed Mater Res., vol. 5, pp. 129-138 (1971).
"Safety and efficacy of the antiseptic chlorhexidine gluconate", A. Rosenberg, S. D. Alatary and AF Peterson, SG&O Nov. 1976, vol. 143, 789-792.
"Chlorohexidine", J. F. Gardner, Phil and K. G. Gray, Disinfection, Sterilization, and Preservation, Third Edition, Lea & Febiger, 1983, 251-270.
"Experimental evaluation of chlorhexidine gluconate for ocular antisepsis", M. B. Hamill, M. S. Osato and K. R. Wilhelms, Antimicrobial Agents and Chemotheraphy, Dec. 1984, pp. 793-796.
"Comparison of 4% Chlorhexidine gluconate in a detergent base (hibiclens) and povidone-iodine (betadine) for the skin preparation of hemodialysis patients and personnel", S. E. Goldblum, J. A. Ulrich et al., Am. Journal of Kidney Diseases, vol. 11, No. 5, Mar. 1983.
"Effect of chlorhexidine on the microflora of the oral cavity", C. R. Schiott, J. Periodont, Res 8, Suppl. 12, 7-10, 1973.
"Chlorhexidine in the prophylaxis of dental diseases", Introduction, Harald Loe, J. Periodont, Res. 8, Suppl. 12, 5-6, 1973.
"Optimal dosage and method of delivering chlorhexidine solutions for the inhibition of dental plaque", B. R. Cumming and Harold Loe, J. Periodont Res. 8, 57-62, 1973.
"The sensitivity of oral streptococci to chlorhexidine", C. R. Schiott and Harold Loe, J. Periodont, Res. 7, 192-194, 1972.
"Chlorhexidine-protein interactions", L. G. Hjeljord, G. Rolla and P. Bonesvoll, J. Periodont, Res. 8, Suppl. 12, 11-16, 1873, 11-35.
"Instrumental Bacteraemia and its prevention", J. P. Mitchell , Norman Slade and K. B. Linton, British Journal of Urology, 454-457.
"1:6-DI-4-Chlorophenyldiguanidohexane (Hibitane) Laboratory investigation of a new antibacterial agent of high potenty", Brit. J. Pharmacol. (1954), 9, 192-196.
"Urinary infection after colporrhapy: its incidence, causation and prevention", M. L. Paterson, W. Barr, Shelia MacDonald, Journal of Obstetrics and Gynecology, 394-401.
"The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of escherichia coli and staphylococcus aureus", W. B. Hugo and A. R. Longworth, J. Pharm. Pharmac., 1966, 18, 569-578.
"A comparison of three guinea-pig sensitization procedures for the detection of 19 reported human contact sensitizers", B. F. J. Goodwin, R. W. R. Crevel and A. W. Johnson, Contact Dermatitis, 1981, 7, 248-258.
"Prevention of urinary infection after prostatectomy", The Lancet, Oct. 22, 1960, 886-888.
"Electron-Microscope study of the effect of chlorhexidine on pesudomonas aeruginosa", R. M. E. Richards and R. H. Cavill, Microbios 26, 85-93, 1979.
"Studies on the mode of action of the antibacterial agent chlorhexidine on clostridium perfringens 1 adsorption of chlorhexidine on the cell, its antibacterial activity and physical effects", W. B. Hugo and Diana C. Daltrey, Microbios, 1974, 11, 119-129.
"The colloidal properties of chlorhexidine and its interaction with some macromolecules", D. D. Heard and R. W. Ashworth, J. Pharm. Pharmac., 1968, 20, 505-512.
"Studies on the mode of action of the antibacterial agent chlorhexidine on clostridium perfringens, 2 Effect of chlorhexidine on metabolism and on the cell membrane", D. C. Daltrey and W. B. Hugo, Microbios, 1974, 11, 131-146.
"Comparison of 70% alcohol, 10% Povidone-Iodine and 25% chlorhexidine for cutaneous disinfection in IV Therapy, D. G. Maki, C. Alvarado et al.
"Modification of HIV envelope lipids, protein structure and infectivity by AL721, a unique lipid mixture", F. T. Crews, J. Laurence, R. McElhane

Affiliated with

Also associated with

Rating

Infection-resistant compositions, medical devices and surfaces a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Infection-resistant compositions, medical devices and surfaces a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Infection-resistant compositions, medical devices and surfaces a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-33147