Inert core implant pellet

Details Inert core implant pellet Inert core implant pellet

1978-05-05

1979-12-25

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 16, 424 19, 424 22, A61K 922, A61K 924

Patent

active

041805607

ABSTRACT:
A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared which has an inert spherical core of a diameter of about 2-10 mm and a uniform coating of about 0.05-1 mm completely covering the core, the coating comprising about 5-99% suitable carrier and 1-95% drug. A drug may be administered at a constant rate over a chosen period by implanting the novel pellet and the release is substantially abruptly terminated at the end of said period without removing the pellet.

REFERENCES:
patent: 4096239 (1978-06-01), Katz et al.
Cooney A. I. Ch. E. Jl. vol. 17, No. 3, pp. 754-756, "Slow Dissolution of Implanted Beds of Spherical Particles as a Method for Prolonged-Release Medication".

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