Inert core implant pellet

Details Inert core implant pellet Inert core implant pellet

1976-10-26

1978-06-20

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

128260, 424238, A61K 922, A61K 31565

Patent

active

040962393

ABSTRACT:
A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared which has an inert spherical core of a diameter of about 2-10 mm and a uniform coating of about 0.05-1 mm completely covering the core, the coating comprising about 5-99% suitable carrier and 1-95% drug. A drug may be administered at a constant rate over a chosen period by implanting the novel pellet and the release is substantially abruptly terminated at the end of said period without removing the pellet.

REFERENCES:
patent: RE28536 (1975-09-01), Reed
patent: 2921883 (1960-01-01), Reese et al.
patent: 3443561 (1969-05-01), Reed
patent: 3499445 (1970-03-01), Reed

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