Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2007-06-08
2010-12-07
Coleman, Brenda L (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
07847094
ABSTRACT:
Disclosed herein is an industrial preparation of Quetiapine by the reaction of 11-piperazinyldibenzo[b,f][1,4]-thiazepine or its salt with 2-(2-chloroethoxy)ethanol in presence of an organic or inorganic base under neat or aqueous condition to form 11-[4-{2-(2-hydroxyethoxy)ethyl}-1-piperazinyl]dibenzo[b,f]-[1,4]thiazepine. The quetiapine free base obtained is further converted to its hemi-fumarate salt.
REFERENCES:
patent: 4879288 (1989-11-01), Warawa et al.
patent: 2004/0220400 (2004-11-01), Diller et al.
patent: 0 282 236 (1988-09-01), None
Jadhav Balasaheb Ganpat
Kumar Ashok
Mahale Ganesh Devidas
Patil Swapnali Hemant
Rana Ragneshkumar
Blank Rome LLP
Coleman Brenda L
IPCA Laboratories Limited
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