Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...
Reexamination Certificate
2007-10-02
2007-10-02
Woitach, Joseph (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
C435S070300, C435S375000, C435S455000, C435S462000, C435S467000
Reexamination Certificate
active
11039523
ABSTRACT:
The present invention provides methods for inducing insulin gene expression in cultured pancreas cells, the method comprising contacting a culture of endocrine pancreas cells expressing a PDX-1 gene with a GLP-1 receptor agonist, wherein the cells have been cultured under conditions such that the cells are in contact with other cells in the culture, thereby inducing insulin gene expression in the ceils. The invention also provides methods of treating a diabetic human subject using the methods of the invention.
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Gouty Dominique
Levine Fred
McGillem Laura
The Regents of the University of California
Townsend and Townsend / and Crew LLP
Woitach Joseph
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