Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Mutation employing a chemical mutagenic agent
Patent
1997-10-27
2000-05-16
Brusca, John S.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Mutation employing a chemical mutagenic agent
435 913, 435 9132, 4352351, 435236, 435325, 435366, 4353723, 435440, 435441, 536 221, 536 231, C12N 1500, C12N 1585, C12P 1934, C07H 2102
Patent
active
060636289
ABSTRACT:
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduced viability of progeny generations of the virus, thereby inhibiting viral replication. In addition to these methods and related compositions, the invention provides methods and combinatorial chemistry libraries for screening ribonucleoside analogs for mutagenic potential.
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Loeb Lawrence A.
Mullins James I.
Brusca John S.
Shibuya Mark L.
University of Washington
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