Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Mutation employing a chemical mutagenic agent
Reexamination Certificate
2005-05-03
2005-05-03
Lacourciere, Karen A. (Department: 1635)
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Mutation employing a chemical mutagenic agent
C435S091300, C435S091320, C435S235100, C435S236000, C435S325000, C435S366000, C435S372300, C435S440000, C435S441000, C536S022100, C536S023100
Reexamination Certificate
active
06887707
ABSTRACT:
The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduced viability of progeny generations of the virus, thereby inhibiting viral replication. In addition to these methods and related compositions, the invention provides methods and combinatorial chemistry libraries for screening ribonucleoside analogs for mutagenic potential.
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Loeb Lawrence A.
Mullins James I.
Lacourciere Karen A.
Townsend and Townsend / and Crew LLP
University of Washington
Vivlemore Tracy
LandOfFree
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