Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1976-09-24
1978-12-19
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Lymphokine
424180, 424181, 536 28, 536 29, A61K 4504, C07H 2102
Patent
active
041306414
ABSTRACT:
The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the polyriboinosinate and polycytidylate complex (rI.sub.n .multidot.rC.sub.n), are modified to yield unpaired bases, (uracil or guanine) along the polycytidylate strand which render the complexes more readily hydrolyzable by nucleases present in living cells. The modified complexes retain their ability to stimulate interferon release by the cells but are rendered more vulnerable to destruction within the cells, the modified complexes being significantly less toxic than the original complexes. In addition, polyinosinate strand now has been prepared to contain 5-16% 2'-O-methyl inosinate residues, designated as (rI.sub.5-20, 2'-MeI).sub.n. The new complex (rI.sub.5-20, 2'-MeI).sub.n .multidot.rC.sub.n, exhibits 100-fold more activity than rI.sub.n .multidot.rC.sub.n as an interferon inducer in human cells.
REFERENCES:
patent: 3843629 (1974-10-01), Scheit et al.
patent: 3845033 (1974-10-01), Harnden
patent: 3980776 (1976-09-01), Ishida et al.
Carter William A.
T'so Paul O. P.
Brown Johnnie R.
Finch Walter G.
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