Multicellular living organisms and unmodified parts thereof and – Nonhuman animal
Patent
1994-12-20
1998-03-03
Chambers, Jasemine C.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
424 937, 424 931, 800DIG5, 4351723, C12N 500, C12N 1500
Patent
active
057237182
ABSTRACT:
The present invention provides methods of producing a canine animal model of cancer. The method comprising introducing a heterologous tumor cell into an pre-mature, preimmunocompetent canine animal under conditions that induce immune tolerance to the tumor cell. The tumor cell is then allowed to proliferate in the canine animal, thereby forming a tumor.
REFERENCES:
patent: 4276282 (1981-06-01), Sugimoto et al.
Tizard, Veterinary Immunology. ISBN 0-7216-8868-3, published by W. B. Saunders Company, p. 157, 1977.
Shifrine, M., et al., "Leukemia Allotransplants in Canine Fetuses: Influence of Host Age and Immune Responsiveness", Proceedings of the Society of Experimental Biology and Medicine, 151:307-309 (1976).
Tizard, I., "Immunity in the Fetus and Newborn", Veterinary Immunology: An Introduction, 3rd vol., CWB Saunders Co., Philadelphia, (1987).
Bates, Robert W. et al. Induction of Permanent Diabetes in Rats by Pituitary Hormones from a Transplantable Mammotropic Tumor, Concomitant Changes in Organ Weights and the Effect of Adrenalectomy, Apr. 1966, pp. 826-836.
Chambers Jasemine C.
Clark Deborah J. R.
St. Joseph's Hospital and Medical Center
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