Induction of immune response by immunization with encapsulated a

Details Induction of immune response by immunization with encapsulated a Induction of immune response by immunization with encapsulated a

1984-05-24

1987-07-14

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

435 68, 4351722, 935 89, 935107, A61K 39395, C12N 1500, C12P 2100

Patent

active

046801740

ABSTRACT:
Cells such as genetically modified cells, e.g., hybridoma, which secrete an antigenic substance are encapsulated within capsule membranes having pores of dimensions sufficient to permit efflux of the antigens secreted by the cells but insufficient to permit traverse of the cells. The capsules are injected into an experimental animal where antigen passing through the pores of the capsule membrane induces lymphocytes to produce antibodies complementary to the antigen. The antibody may be harvested from the circulatory system of the animal. Preferably, lymphocytes are sampled from, e.g., the spleen of the animal, fused with a malignant cell line to produce a hybridoma which synthesizes the antibody in vivo, and the hybridoma is cultured to produce large quantities of monoclonal antibody.

REFERENCES:
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4409331 (1983-10-01), Lim
Brown, Dilley, Levy, Journal of Immunology, vol. 125, No. 3, Sep. 1980, Immunoglobulin Secretion by Mouse X Human Hybridomas: An Approach for the Production of Antiidiotype Reagents Useful in Monitoring Patients with B Cell Lymphoma.
Hatzubai, Maloney, Levy, The Journal of Immunology, vol. 126, No. 6, Jun. 1981, The Use of a Monoclonal Anti-Idiotype Antibody to Study the Biology of a Human B Cell Lymphoma.
Miller et al, New England Journal of Medicine, vol. 306, No. 9, Mar. 4, 1982, Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody.

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