Induction of cytotoxic T-lymphocyte responses

Details Induction of cytotoxic T-lymphocyte responses Induction of cytotoxic T-lymphocyte responses

1992-07-24

1996-12-17

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

4242041, 4242771, 4242831, 424400, A61K 4505, A61K 3912, A61K 3939, A61K 9107

Patent

active

055851037

ABSTRACT:
Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.

REFERENCES:
patent: 3083142 (1963-03-01), Howell et al.
patent: 3790665 (1974-02-01), Glass et al.
patent: 3919411 (1975-11-01), Glass et al.
patent: 4053585 (1976-05-01), Allison et al.
patent: 4117113 (1977-11-01), Allison et al.
patent: 4770874 (1988-09-01), Allison
patent: 4772466 (1988-09-01), Allison et al.
patent: 4778784 (1988-10-01), Dreesman et al.
patent: 4963354 (1990-06-01), Shepard et al.
Phillips, N. C. et al. 1990, Cancer Detect. Prev. (United States), vol. 14, pp. 491-496 (abstract only).
Lidgate, D. M. et al. 1989, Biopharm., vol. 2, No. 9, pp. 28-32.
Korstvedt, H. et al. 1984, Drug & Cosmetic Industry, vol. 135, pp. 36-37.
Takoyuma et al, Vaccine 9:257-265, 1991.
Hunte et al, J. Immunol. 127(3):1244-1250, 1981.
Hunter et al, Vaccine 9:250-256, 1991.
Brugh et al, Am J. Vet Res. 44(1):72-75, 1983.
Kimura et al, Jap. J. Exp. Med. 48(2):149-154, 1978.
Kwak, L. W. et al. (90) in Idiotype Networks in Biology and Medicine, A. Osterhaus & F. Uytdehaag, eds., Elsevier Science Publishers New York, NY., 163-171.
Allison, A. C. et al. (90) Immunol. Today 11:427-429.
Staerz et al., Nature 239:449, 1987.
Murphey-Corb et al., Science 246:1293, 1989.
Asherson et al., Immunology 22:465, 1972.
Berman et al., Int. J. Cancer 2:539-543, 1967.
Letvin et al., Vaccines 87, Cold Spring Harbor Laboratory (1987).
Allison et al., Vaccines 87, Cold Spring Harbor Laboratory (1987).
Allison et al., Immunopharmacology of Infectious Diseases: Vaccine Adjuvants and Modulators of Non-Specific Resistance, pp. 191-201, 1987.
Allison, Immunopotentiation, Elsevier, Excerpta Medica, North-Holland, pp. 73-99, 1973.
Morgan et al., J. Medical Virology 29:74-78, 1989.
Kenney et al., J. Immunological Methods 121:157-166, 1989.
Allison et al., J. Immunological Methods 95:157-168, 1986.
Byars et al., 8 Vaccine 49, 1990.
Allison et al., Molecular Immunology 28(3):279-284, 1991.
Allison et al., Technological Advances in Vaccine Development, pp. 401-409, 1988.
Byars et al., 5 Vaccine 223, 1987.
Allison, "Non-Specific" Factors Influencing Host Resistance, pp. 247-258, (Karger, Basel 1973)*.
Mitchell et al., Journal of Clinical Oncology 8(5):856-869, 1990.
Takahashi et al., Proc. Natl. Acad. Sci USA 85:3105-3109, 1988.
Hunter et al., J. Immunology 133(6):3167, 1984.
Hunter et al., J. Immunology 127:1244, 1981.
Rickman et al., The Lancet 337:998, 1991.
Sanchez-Pescador et al., J. Immunology 141(5):1720-1727, 1988.
Morein et al., Immunological Adjuvants and Vaccines, Plenum Press, Published in cooperation with NATO Science Affairs Division, pp. 153-161.
Takahashi et al., Nature, 344:873, 1990.
Allison et al., J. Immunological Methods 95:157-168, 1986.
Eppstein et al., Advanced Drug Deliver Reviews, 4:233-253, 1990.
Pluronic Surfactants brochure.
Whittaker Bioproducts, Inc., brochure, 1989.
Khusmith et al., Science 252:715, 1991.
Shen et al., Science 252:440, 1991.
Rosenthal, New York Times.
Kolata, New York Times, Apr. 19, 1991.
Rennie, Scientific American, Jul. 1991, p. 24.
Campbell et al., J. Immunology 139:2825, 1987.
Campbell et al., J. Immunology 145:1029, 1990.
Kwak et al., Blood 76(11):2411, 1990.
Wraith et al., J. gen Virol 66:1327, 1985.
Goldstein et al., Chapter 4, mAbs To Human Lymphocyte Surface Antigens, p. 71.
C. K. Stover et al., Nature 351:456-460, 1991.
Byars, N. E. et al. 5 Vaccine 223-228 (1987).

Affiliated with

Also associated with

Rating

Induction of cytotoxic T-lymphocyte responses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Induction of cytotoxic T-lymphocyte responses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Induction of cytotoxic T-lymphocyte responses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1989311