Induction of cytotoxic T-lymphocyte responses

Details Induction of cytotoxic T-lymphocyte responses Induction of cytotoxic T-lymphocyte responses

1995-06-07

1997-12-09

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

4241841, 4242041, 4242771, 4242831, A61K 4505, A61K 3900, A61K 4700, A61K 3939

Patent

active

056957700

ABSTRACT:
Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.

REFERENCES:
patent: 4770874 (1988-09-01), Allison et al.
Brugh et al 1983 Am J Vet Res 44 (1) pp. 72-75, Jan. 1, 1983.
Mackewicz et al 1991 J Clin Invest 87 pp. 1462-1466, Apr. 1991.
Nicholas et al 1991 Virology 182 pp. 664-671, Jan. 1, 1991.
Rouse et al. 1988 Reviews of Inf. Dis. 10 (1) pp. 16-33, Jan. 1, 1988.

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