Induction of cytotoxic T-lymphocyte responses

Details Induction of cytotoxic T-lymphocyte responses Induction of cytotoxic T-lymphocyte responses

1994-12-07

1998-01-20

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

4242041, 4242081, 4242771, 4242751, 4242831, 424400, A61K 39000, A61K 39008, A61K 3912, A61K 39390

Patent

active

057098603

ABSTRACT:
Methods and compositions useful for inducing a cytotoxic T lymphocyte response (CTL) in a human or domesticated or agriculturally important animal. The method includes the steps of providing the antigen to which the CTL response is desired and providing an antigen formulation which comprises, consists, or consists essentially of two or more of a stabilizing detergent, a micelle-forming agent, and an oil. This antigen formulation is preferably lacking in an immunostimulating peptide component, or has sufficiently low levels of such a component that the desired CTL response is not diminished. This formulation is provided as a stable oil-in-water emulsion.

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