Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1996-06-28
1999-09-14
Hutzell, Paula K.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4242771, 4242271, 4242081, 4242041, 424 9321, 514 2, 514 21, A01N 6300, A61K 3912, A61K 3900, A61K 3929
Patent
active
059519754
ABSTRACT:
The present invention relates to prophylactic and therapeutic methods of anti-tumor immunization. These methods are based on cross-priming a mammalian host to natural MHC class I restricted tumor antigens with an artificial tumor antigen. A primary tumor is resected from the patient and a population of tumor cells are cultured in vitro. These cultured tumor cells are loaded with an artificial target antigen. The loaded tumor cells are inactivated and introduced into the patient either simultaneous or subsequent to a direct immunization of the patient with the same or substantially the same artificial target antigen. This method of coupled host immunization promotes a tumor specific cytotoxic T lymphocyte (CTL) immune response against multiple, undefined natural tumor antigens expressed on the unmodified tumor cell surface.
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Falo, Jr. Louis D.
Rock Kenneth L.
Bansal Geetha P.
Dana-Farber Cancer Institute
Hutzell Paula K.
Meyers Diane R.
Silverman Arnold B.
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