Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-01-04
2011-01-04
Bowman, Amy (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S023100, C514S04400A
Reexamination Certificate
active
07863436
ABSTRACT:
The invention relates to the induction of apoptosis by inhibition of the sirtuin SIRT1 expression, in particular the induction of apoptosis in tumour cells. Materials and methods for inhibiting SIRT1 expression are provided, including RNA interference methods. In particular, the invention provides a method of treating a proliferative disease comprising administering to an individual in need thereof an effective amount of a SIRT1 inhibitor.
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Grozinger et al., “Deacetylase enzymes: Biological functions and the use of small-molecule inhibitors”, Chemistry and Biology, vol. 9, No. 1, Jan. 2002, pp. 3-16, XP00233015.
Bowman Amy
Nixon & Vanderhye P.C.
The University of York
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