Induction of apoptosis by cellular stress

Details Induction of apoptosis by cellular stress Induction of apoptosis by cellular stress

2006-10-10

2006-10-10

Yu, Misook (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S004000, C435S007200, C436S501000, C436S518000

Reexamination Certificate

active

07118862

ABSTRACT:
The invention provides methods of screening to identify compounds that modulate the ability of a protein to translocate to the mitochondria when a cell is subjected to cellular stress. Such compounds can be useful to modulate the level of apoptosis in a cell. For example, compounds identified according to the methods described herein can be used to treat disorders characterized by excessive apoptosis, e.g., a neurological disorder, or insufficient apoptosis, e.g., cancer.

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