Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-01-26
1996-12-31
Crouch, Deborah
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
935 53, 935 55, 935 60, 935 65, A61K 4800, C12N 1500
Patent
active
055894666
ABSTRACT:
A method for delivering an isolated polynucleotide such as DNA or RNA, to the interior of a cell in a mammal comprising the injection of an isolated polynucleotide into a muscle of the mammal where the polynucleotide is taken up by the cells of the muscle and exerts a therapeutic effect on the mammal. The method can be used to deliver a therapeutic polypeptide to the cells of the mammal, to provide an immune response upon in vivo translation of the polynucleotide, to deliver antisense polynucleotides, to deliver receptors to the cells of the mammal or to provide transitory gene therapy.
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Carson Dennis A.
Felgner Philip L.
Malone Robert W.
Rhodes Gary H.
Wolff Jon A.
Crouch Deborah
Vical Incorporated
Wisconsin Alumni Research Foundation
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