Induction and inhibition of apoptosis

Details Induction and inhibition of apoptosis Induction and inhibition of apoptosis

1993-04-14

1996-03-19

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

055004326

ABSTRACT:
A method for inducing apoptosis in target cells employs designed enediynes which are triggered to become chemically reactive when bound to target cells. Conversely, a method for inhibiting the induction of apoptosis employs compounds which compete with the above compounds which induce apoptosis, but which are chemically unreactive with respect to the target cells.

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Nicolaou et al. J. Am. Chem. Soc. (1993), 115, 7944-7953.
Nicolaou et al. Angew. Chem. It. Ed. Eng (1989), 28, 1272-1275.
Mair et al. Tet. Letters (1991), 32, 3679-3682.
Nicolaou et al. J. Am. Chem. Soc. (1992), 114, 9279-9282.
Nicolaou et al. Angew. Chem. It. Ed. Eng. (1991), 30, 418-420.
Nicolaou et al. Angew. Chem. It. Ed. Eng. (1991), 30, 1387-1416.

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