Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-08
1999-01-12
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424 932, 424 931, 424 851, 4352402, A61K 3800, A01N 3718
Patent
active
058589635
ABSTRACT:
A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.
REFERENCES:
Sykes et al. "Xenograft Tolerance," Immunological Reviews, vol. 141: 213-244, Oct. 1994.
Sablinski et al., Xenotransplantation, 2:264-270 (1995).
Giovino et al., Porcine Specific Cytokines Enhance Porcine Bone Marrow Engraftment and Survival in a Xenogeneic Stromal Environment (Abstract), 3rd International Congress for Xenotransplantation, Boston, Oct. 1995.
Sablinski et al., Long Term Discordant Xenogeneic (Porcine To Primate) Bone Marrow Chimerism in a Monkey Treated With Porcine-Specific Stem Cell Factor and IL-3 (Abstract), 3rd International Congress for Xenotransplantation, Boston, Oct. 1995.
Yang et al., Enhanced Xenogeneic Hematopoietic Chimerism In Mice Receiving Porcine Donor-Specific Growth Factors (Abstract), 3rd International Congress for Xenotransplantation, Boston, Oct. 1995.
Hawley Robert J.
Monroy Rodney L.
Ronath Paul D.
Rosa Margaret D.
Schacter Bernice Z.
BioTransplant, Inc.
Chambers Jasemine C.
Hauda Karen M.
Lillie Raymond J.
Olstein Elliot M.
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