Inducing analgesia by implantation of cells releasing neuroactiv

Details Inducing analgesia by implantation of cells releasing neuroactiv Inducing analgesia by implantation of cells releasing neuroactiv

1986-05-23

1988-06-28

Rosenbaum, C. Fred

Surgery

Means for introducing or removing material from body for...

Material introduced into and removed from body through...

514818, 6048911, A61F 266

Patent

active

047536357

ABSTRACT:
A method of inducing analgesia or reducing pain is described. The method involves implanting in the central nervous system of a host susceptible to pain, living material capable of releasing effective amount of analgesic substance when interacted with a stimulus which induces said material to release analgesic amount of said substance. The procedure described herein reduces sensitivity to intractable pain.

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patent: 4388236 (1983-06-01), Stein
Freed et al., Transplanted Adrenal Chromaffin Cells in Rat Brain Induce Lesion Induced Rotational Behavior, Nature 292: 351-352 (1981).
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Mizobe, Fumio and Livett, Bruce G., Nicotine Stimulates Secretion of Both Catecholamines and Acetylcholinesterase from Cultured Adrenal Chromaffin Cells, Journal of Neuroscience, vol. 3, No. 4, pp. 871-876, Apr. 1983.
Olson et al., Transplantation in Parkinsons Disease, Arnals of the New York Academy of Sciences, vol. 457, pp. 105-126, 1985.
J. Neurochem 36(3) 1981 886-892, Advances in Biochemical Psychopharmocology, vol. 22, pp. 571-580.

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