Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-11-20
2007-11-20
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Vector, per se
C530S350000, C530S327000, C530S324000, C536S023100, C536S023400, C536S023720, C536S024100
Reexamination Certificate
active
10763976
ABSTRACT:
Inducible gene expression systems and a method thereof. A first inducible gene expression system includes a first vector comprising at least one retroviral promoter and at least one factor to induce the retroviral promoter. At least one gene product is expressed in proportion to retroviral promoter induction. The method includes providing a first vector comprising at least one retroviral promoter and providing at least one factor corresponding to the retroviral promoter. The retroviral promoter is induced with the at least one factor. At least one protein is expressed based on the induction of the retroviral promoter. A second inducing expression system includes a first vector comprising at least one retroviral promoter, an inducer for the retroviral promoter, and at least one protein expressed in proportion to retroviral promoter induction.
REFERENCES:
patent: 6096538 (2000-08-01), Kingsman et al.
patent: 6835568 (2004-12-01), Chang et al.
Choi, Eun-A. et al., “The Role of Poly (A) Tail Stability in the Abilitty of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element to Stimulate Gene Experession”, American Society of Gene Therapy Abstracts of Scientific Presentations: The 5th Annual meeting of the American Society of Gene Therapy, Jun. 5-9, 2002, Abstract No. 439.
Ketteler, Robin et al., “The Woodchuck Post-Transcriptional Regulatory Element WPRE Can Overcome Restriction in Tetroviral gene Expression in Embryonic Stem Cells”, American Society of Gene Therapy Abstracts of Scientific Presentations: The 5th Annual meeting of the American Society of Gene Therapy, Jun. 5-9, 2002, Abstract No. 87.
Daisuke, Nagakubo, et al., “Expression of CCR9 in HTLV-1+ T Cells and ATL Cells Expressing Tax”, Int. J. Cancer: 120, 1591-1597 (2007).
Shayakhmetov, D. et al., “Use of the Bovine Leukaemia Virus LTR U3 Promoter for Expressing Antisense Antiviral RNAs and Competitive Inhibition of Viral Infection in Cell Culture”, Journal of General Virology (1997), 78, 1941-1948.
Pare, Marie-Eve, et al., “A New Sensitive and Quantitative HTLV-I-Mediated Cell Fusion Assay in T Cells”, VIROLOGY 338 (2005) 309-322.
Katoh, Iyoko, et al., “Bovine Leukemia Virus Trans-Activator p38tax Activates Heterologous Promoters with a common sequence Known as a cAMP-Responsive Element or the Binding Site of a Cellular transcription Factor ATF”, The EMBO Journal, vol. 8 No. 2, pp. 497-503 (1989).
Brooks, Patricia A. et al., “Activation of BLV Transcription by NF-kB and Tax”, Virology 243, 94-98 (1998) Article No. VY989035.
Pankow, Rudiger, et all, “The HTLV-I Tax Protein Transcriptionally Modulates OX40 Antigen Expression”, The Journal of Immunology (2000) 165: 263-270.
Bremel Robert D.
Eakle Kurt A.
Harms Jerome S.
Splitter Gary A.
Guzo David
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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