Inducible nitric oxide synthase dimerization inhibitors

Details Inducible nitric oxide synthase dimerization inhibitors Inducible nitric oxide synthase dimerization inhibitors

2005-11-28

2010-11-02

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S361000

Reexamination Certificate

active

07825256

ABSTRACT:
The present invention relates to compounds and methods useful as inhibitors of nitric oxide synthase. Certain compounds of the subject invention have the following structural formula:wherein T, X, and Y are independently selected from the group consisting of CR4, N, NR4, S, and O; U is selected from the group consisting of CR10and N; V is selected from the group consisting of CR4and N; W and W′ are independently selected from the group consisting of CH2, CR7R8, NR9, O, N(O), S(O)qand C(O); n, m and p are independently an integer from 0 to 5; q is 0, 1, or 2; and other substituents are as defined herein. Other compounds of the subject invention have structural formulas as defined herein. Also disclosed herein are pharmaceutical compositions comprising the compounds of the subject invention.

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