Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2003-05-28
2008-11-25
Sullivan, Daniel M (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S070100, C435S070300, C435S091100, C435S091300, C435S325000, C435S365000, C435S358000, C435S369000, C536S023400, C536S023500
Reexamination Certificate
active
07455988
ABSTRACT:
Compositions and methods for the inducible expression of genes in eukaryotic cells. Expression of a nucleotide sequence of interest is controlled by a regulatory fusion protein that consists of a transcription blocking domain and a legends-binding domain. When the cognate ligand for the ligand-binding domain is present, transcription of the nucleotide sequence of interest is blocked. Upon removal of the cognate ligand, the nucleotide sequence of interest is transcribed. The method is useful for large scale production of a desired product in eukaryotic cells.
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Dou Changlin
Fandl James P.
Gregg, Esq. Valeta
Regeneron Pharmaceuticals Inc.
Smeland, Esq. Tor
Sullivan Daniel M
Yang Ying-Zi
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