Inducible endothelial surface protein mediating melanoma cell ad

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

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5303877, 5303888, C07K 100, C07K 1400, C07K 1700, C07K 1600

Patent

active

061661791

ABSTRACT:
Monoclonal antibody E1/6, or fragments thereof, blocks adhesion to the vascular endothelium of certain pathophysiological cells. Monoclonal antibody E1/6, or fragments thereof, and the glycoprotein recognized by the E1/6 antibody, are used pharmaceutically, therapeutically, and diagnostically in the treatment of these pathophysiological disorders. Compositions, methods of treating, and methods of diagnosing are disclosed.

REFERENCES:
Bevilacqua et al. J. Clin. Invest. 76:2003-2011, 1985.
Vanderheide et al. J. Exp. Med. 175:1433-1442, 1992.
Sherman-Gold, Genetic Engineering News, Jul. 1993, pp. 6, 7, 14.
Herbert et al., Eds. Dictionary of Immunology, Blackwell Scientific Publications, 1985, p. 77.

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