Inducible defensin peptide from mammalian epithelia

Details Inducible defensin peptide from mammalian epithelia Inducible defensin peptide from mammalian epithelia

1994-05-24

1996-08-27

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 536 231, 536 235, 435 691, 435 6, 4353201, 4351723, C07K 1447, A61K 3817

Patent

active

055501095

ABSTRACT:
The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.

REFERENCES:
patent: 5202420 (1993-04-01), Zasloff et al.
patent: 5242902 (1993-09-01), Murphy et al.
patent: 5422424 (1995-06-01), Selsted et al.
Paul T. Brey, et al., "Role of the integument in insert immunity: Epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells," Pro. Natl. Acad. Sci. USA, vol. 90 (Jul. 1993) pp. 6275-6279.
Gill Diamond et al., "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA," Proc. Natl. Acad. Sci. USA, vol. 88 (1991) pp. 1-6.
Michael E. Selsted et al., "Purification, Primary Structures, and Anti-bacterial Activities of Defensins, a New Family of Antimicrobial Peptides from Bovine Neutrophils," J. Biol. Chem. vol. 268, No. 9 (1993) pp. 6641-6648.
Thomas Ganz et al., "Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells," Medical Microbiology and Immunology, vol. 181 (1992) 99-105.
Diamond & Bevins, "Endotoxin up-regulates expression of an antimicrobial peptide gene in mammalian airway epithelial cells," Chest. 1994 Mar. 105 (3 Suppl) 51s-52s, 1994.

Affiliated with

Also associated with

Rating

Inducible defensin peptide from mammalian epithelia does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inducible defensin peptide from mammalian epithelia, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inducible defensin peptide from mammalian epithelia will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1056222