Inducible defensin peptide from mammalian epithelia

Details Inducible defensin peptide from mammalian epithelia Inducible defensin peptide from mammalian epithelia

1995-05-26

1997-08-12

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 435 691, 4353201, 4352523, 4351723, 530324, C12N 1512, C07K 1447, A61K 3817

Patent

active

056567383

ABSTRACT:
The present invention relates to an inducible antimicrobial peptide designated lingual antimicrobial peptide (LAP) which has antibacterial and antifungal activity and which can be obtained from mammalian epithelium. The prepro- and the pro- precursors of LAP are also provided. The present invention also relates to cDNA encoding LAP, the prepro- precursor or the pro-lingual precursor. In addition, methods of treating microbial infection of the epithelia are provided. Such infections can be treated by contacting the epithelia with an antimicrobially effective amount of a purified mammalian epithelial LAP or by administering a component which cause endogenous production or up-regulation of LAP.

REFERENCES:
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patent: 5422424 (1995-06-01), Selsted et al.
Paul T. Brey, et al., "Role of the integument in insect immunity: Epicuticular abrasion and induction of cecropin synthesis in cuticular epithelial cells," Pro. Natl. Acad. Sci. USA, vol. 90 (Jul. 1993) pp. 6275-6279.
Gill Diamond et al., "Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: Peptide isolation and cloning of a cDNA," Proc. Natl. Acad. Sci. USA, vol. 88 (1991) pp. 1-6.
Michael E. Selsted et al., "Purification, Primary Structures, and Anti-bacterial Activities of Defensins, a New Family of Antimicrobial Peptides from Bovine Neutrophils," J. Biol. Chem. vol. 268, No. 9 (1993) pp. 6441-6648.
Thomas Ganz et al., "Defensins: microbicidal and cytotoxic peptides of mammaliam host defense cells," Medical Microbiology and Immunology, vol. 181 (1992) 99-105.
Diamond & Bevins, "Endotoxin up-regulates expression of an antimicrobial peptide gene in mammalian airway epithelial cells," Chest. 1994 Mar. 105 (3 Suppl) 51s-52s, 1994.

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