Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1984-02-03
1984-12-04
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
260112R, 424 85, 424 88, 424177, A61K 3512, A61K 3702, C07G 700, C07G 1500
Patent
active
044864094
ABSTRACT:
This invention relates to a new composition of matter, and more particularly to a novel thymic factor isolated in purified form from mammalian thymus tissue which induces immature bone marrow cells to differentiate into competent suppressor T-cells (T.sub.s). This novel thymic factor, which can also be called inducer of T-suppressor cells (iT.sub.s), has a molecular weight of approximately 65,000 daltons, as determined by gel filtration, a pI of 4.2-4.5, and is heat stable up to about 80.degree. C. iT.sub.s induces immature bone marrow cells to differentiate into cells which exhibit a phenotypic marker of suppressor T-cells and which when adoptively transferred repress reconstitution of the immune response in irradiated, thymectomized mice. An antibody has also been raised to iT.sub.s. This invention also relates to therapeutic methods and fields of use for iT.sub.s.
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