Induced chromosomal deletion

Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Via microinjection of dna into an embryo – egg cell – or...

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800 21, 435446, 435463, C12N 1500

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active

059946202

ABSTRACT:
Disclosed is a method for the production of deletions in the chromosomal DNA of a single eukaryotic cell. More specifically, the method involves the creation of either random chromosomal deletions, or chromosomal deletions within a predetermined genetic loci. The deletions are created by integration of a DNA construct into the chromosomal DNA of the single eukaryotic cell, followed by spontaneous or irradiation induced deletion of the DNA construct from the chromosomal DNA. Also, disclosed is a method for the production of deletions in the chromosomal DNA of a multicell organism using a DNA construct.

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