Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-08-02
1991-02-05
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3140
Patent
active
049905309
ABSTRACT:
Injections containing anhydrous sodium indomethacin and methods for producing injections containing an hydrous sodium indomethacin which comprise converting a solution of indomethacin to a solution of sodium indomethacin by adding dropwise an aqueous solution of a carbonate of sodium, followed by freeze-drying and heating.
The injections of the present invention are practically useful indomethacin injections in which sodium indomethacin anhydride has high safety and chemically high purity and stability, and the lyophilized pharmaceutical preparations are excellent also in that redissolution thereof is facilitated. By the methods for the production of the present invention, it is possible to produce said anhydrous sodium indomethacin efficiently.
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Hasegawa Masatoshi
Matsuda Shu
Takenaka Hiroshi
Henley III Raymond J.
Robinson Douglas W.
Sumitomo Pharmaceuticals Company Limited
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