Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2006-02-07
2006-02-07
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C546S277400
Reexamination Certificate
active
06995263
ABSTRACT:
This invention relates to compounds of the formulawherein one of R6, R7and R8isand X, Y1to Y4, R1to R14and n are as defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
REFERENCES:
patent: 2004/0209936 (2004-10-01), Bratton et al.
patent: 2163150 (1986-02-01), None
patent: WO 02/08188 (2002-01-01), None
patent: WO 03/018553 (2003-03-01), None
patent: WO 03/027069 (2003-04-01), None
patent: WO 03/027076 (2003-04-01), None
patent: WO 03/040107 (2003-05-01), None
patent: WO 03/074051 (2003-09-01), None
patent: WO 03/084916 (2003-10-01), None
patent: WO 2004/063190 (2004-07-01), None
patent: WO 2004/073606 (2004-09-01), None
Nugent, et al., “Potentiation of Glucose Uptake in 3T3-L1 Adipocytes by PPARγ Agonists Is Maintained in Cells Expressing a PPARγ. . . ” Molecular Endocrinology 15(10): 1729-1738 (2001).
Anal. Biochem. 257: 112-119.
Belostotskii, Anatoly M., et. al., Tetrahedron Lett (1994), 35(28), 5075-6.
E.J. Corey, et. al., Am. Chem. Soc (1987) 109, 5551-5553.
Guerre-Millo, et. al., J. Biol Chem (2000) 275: 16638-16642.
Lobiner, et. al., Tetrahedron Lett. (1984), 25, 2535-3536.
S.W. McCombie, et. al., Bioorganic & Medicinal Chemistry Ltrs 13 (2003) 567-571.
Oliver, et. al., Proc Nat Acad Sci USA (2001) 98: 5306-11.
P.V. Ramachandran, e.t al., Tetrahedron: Asymmetry (1994) 5, 1061-1074.
TETRAHEDRON Letters 43 (42), 7617-7619 (2002).
Ackermann Jean
Aebi Johannes
Binggeli Alfred
Grether Uwe
Hirth Georges
Freistein Andrew B.
Hoffmann-La Roche Inc.
Johnston George W.
McKane Joseph K.
Rocha-Tramaloni Patricia S.
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