Indolone derivatives, their preparation and their application in

Details Indolone derivatives, their preparation and their application in Indolone derivatives, their preparation and their application in

1989-08-02

1991-04-23

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514254, 544360, 544362, 544373, 548485, 548486, C07D40106, C07D40306, A61K 3147, A61K 31495

Patent

active

050100793

ABSTRACT:
An indolone derivative is useful for the treatment of anxiety, depression and schizophrenia and is a 5HT.sub.1A agonist and 5HT.sub.2 antagonist, which is a compound of formula (I): ##STR1## in which R.sub.1 is a hydrogen or halogen atom or a (C.sub.1-4)alkyl radical,

REFERENCES:
patent: 3188313 (1965-06-01), Archer
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patent: 3732248 (1973-05-01), Canas-Rodriguez et al.
patent: 4883795 (1989-11-01), Lowe, III et al.
Kulkarni et al. Drugs of Today, 24 p. 175 (1988).
Glennon, J. Med. Chem. 30 p. 1 (1987).
Taborsky et al., "The Synthesis and Preliminary Pharmacology of Some 9H-Pyrido[3,4-b]indoles (.beta.-Carbolines) and Tryptamines Related to Serotonin and Melatonin", Journal of Medicinal Chemistry, vol. 7, No. 2, Mar. 1964, pp. 135-141.

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