Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-08-20
2000-11-14
Stockton, Laura L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142352, 514323, 544143, 544144, 546201, 548455, 548460, A61K 31404, C07D40306
Patent
active
061471062
ABSTRACT:
The present invention relates to organic molecules capable of modulating, regulating and/or inhibiting protein kinase signal transduction. Such compounds are useful for the treatment of diseases related to unregulated protein kinase signal transduction, including cell proliferative diseases such as cancer, atherosclerosis, arthritis and restenosis and metabolic diseases such as diabetes. The present invention features indolinone compounds that potently inhibit protein kinases and related products and methods. Inhibitors specific to the FLK protein kinase can be obtained by adding chemical substituents to the 3-[(indole-3-yl)methylene]-2-indolinone, in particular at the 1' position of the indole ring. Indolinone compounds that specifically inhibit the FLK and platelet derived growth factor protein kinases can harbor a tetrahydroindole or cyclopentano-b-pyrrol moiety. Indolinone compounds that are modified with substituents, particularly at the 5 position of the oxindole ring, can effectively activate protein kinases. This invention also features novel hydrosoluble indolinone compounds that are tyrosine kinase inhibitors and related products and methods.
REFERENCES:
patent: Re36256 (1999-07-01), Spada et al.
patent: 4002749 (1977-01-01), Rovnyak
patent: 4053613 (1997-10-01), Rovnyak et al.
Beilstein Reg. No.: 252929 Beilstein, 1923.
Hirth Klaus Peter
McMahon Gerald
Shawver Laura Kay
Sun Li
Tang Peng Cho
Stockton Laura L.
Sugen Inc.
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