Indoline-sulfonamides compounds

Details Indoline-sulfonamides compounds Indoline-sulfonamides compounds

2007-05-10

2010-06-22

Krass, Frederick (Department: 1612)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S359000

Reexamination Certificate

active

07741495

ABSTRACT:
A series of indoline-sulfonamide compounds is disclosed. The formula of indoline-sulfonamide compounds is shown as formula (I). In formula (I), R1is H or halogen; R2is Ar, Ar—C(O)—, Ar—CH2—, Ar—SO2—, Ar—O—C(O),or R″—C(O)—, and Ar is a substituted or unsubstituted C5-C20 aryl, cyclyl, heterocyclyl, or heteroaryl, R′ and R″ independently is C1-C10 alkyl, or C1-C10 alkoxyl; and R3is C5-C15 aryl or C1-C10 alkyl. The indoline-sulfonamide compounds disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier.

REFERENCES:
Chang et. al. Journal of Medicinal Chemistry (2006) 49:6656-6659.
Dorwald F. A. (Side reactions in organic synthesis, 2005, Wiley, VCH, Weinheim, p. IX of Preface).

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