Indoline and tetrahydro-quinolines as prodrugs for tumour...

Details Indoline and tetrahydro-quinolines as prodrugs for tumour... Indoline and tetrahydro-quinolines as prodrugs for tumour...

2007-02-20

2007-02-20

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S412000, C514S311000, C548S491000, C548S490000

Reexamination Certificate

active

10468743

ABSTRACT:
Compounds of the general formula I or IA or a salt in which X is H, Y is a leaving group, R1preferably being an aromatic DNA binding subunit are prodrug analogues of duocarmycin. The compounds are expected to be hydroxylated at the carbon atom to which X is joined, by cytochrome P450, in particular by CYP1B1, expressed at high levels in tumours. The prodrug is expected to be activated preferentially in tumour cells, where it will act as a DNA alkylating agent preventing cell division

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