Indolicidin analogs with anti-microbial activity

Details Indolicidin analogs with anti-microbial activity Indolicidin analogs with anti-microbial activity

2006-10-03

2006-10-03

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S327000

Reexamination Certificate

active

07115572

ABSTRACT:
The present invention relates to three single tryptophan analogs ILPWKLPLLPLRR-amide (IL4) (SEQ ID NO: 1), ILPLKLPWLPLRR-amide (IL8) (SEQ ID NO: 2) and ILPLKLPLLPWRR-amide (IL11) (SEQ ID NO: 3), of Indolicidin, a cationic tridecapeptide amide found in the granules of bovine neutrophils, the analogs having the amino acid only at the 4th, 8thor 11thposition from the N-terminal, with leucine at its all other conventional positions, the analogs selectively having only anti-microbial activity and no hemolytic activity of Indolicidin, and thereby providing therapeutic options and a method thereof.

REFERENCES:
patent: 6180604 (2001-01-01), Fraser et al.
Subbalakshmi et al. Requirements for antibacterial and hemolytic activities . . . FEBS Letters. 1996, vol. 395, pp. 48-52.
Subbalakshmi et al. Biochemical and Biophysical Research Communications. 2000, vol. 274, pp. 714-716.

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