Indoles having anti-diabetic activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S215000, C548S227000, C548S250000, C548S253000, C514S374000, C514S381000, C514S382000

Reexamination Certificate

active

07625933

ABSTRACT:
Indoles of Formula I having —X-aryl-(CH2)x-oxazolidinedione and —X-heteroaryl-(CH2)x-oxazolidinedione substituents on the N atom of the indole ring, where x is 0 or 1, and —X— is a bond or —CH2—, and their thiazolidinedione analogs, are PPAR gamma agonists or partial agonists and are useful in the treatment and control of type II diabetes, including hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

REFERENCES:
patent: 7186746 (2007-03-01), Acton et al.
patent: 7345085 (2008-03-01), Acton et al.
patent: 7393960 (2008-07-01), Acton et al.
patent: WO 01/30343 (2001-05-01), None
patent: WO 02/08188 (2002-01-01), None
patent: WO 2004/019869 (2004-03-01), None
patent: WO 2004/020408 (2004-03-01), None
patent: WO 2004/020409 (2004-03-01), None
patent: WO 2004/020409 (2004-11-01), None

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