Indoles having anti-diabetic activity

Details Indoles having anti-diabetic activity Indoles having anti-diabetic activity

2008-07-01

2008-07-01

McKane, Joseph (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S379000

Reexamination Certificate

active

07393960

ABSTRACT:
Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.

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Liu et al., “Selective PPARg modulators with improved pharmacological profiles”, Bioorg. Med. Chem. Lett., 15, 2005, 2437-2440.

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