Indolealkyl derivatives of benzodioxanmethylamine

Details Indolealkyl derivatives of benzodioxanmethylamine Indolealkyl derivatives of benzodioxanmethylamine

1996-10-30

1998-05-12

Lambkin, Deborah

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D40500

Patent

active

057507244

ABSTRACT:
The compounds of formula I: ##STR1## wherein R.sup.1, R.sup.4 and R.sup.5 are, independently, hydrogen, alkyl, alkoxy, aralkoxy, alkanoyloxy, hydroxy, halo, trifluoromethyl, amino, mono- or di-alkylamino, alkanamido, or alkanesulfonamido; or, R.sup.1 is defined as above and R.sup.4 and R.sup.5, taken together, are ortho substituted methylenedioxy, ethylenedioxy, or propylenedioxy; R.sup.2 and R.sup.3 are, independently, hydrogen or alkyl; n is 3 or 4; or pharmaceutically acceptable salts thereof, are useful in the treatment of depression and related disorders.

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Cornfield et al., "MDL 73005EF: partial agonist at the 5-HT.sub.1A receptor negatively linked to adenylate cyclase", European Journal of Pharm., 173 (1989) 189-192.

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