Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-04-26
2009-02-17
Solola, Taofiq A (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S468000, C548S491000
Reexamination Certificate
active
07491744
ABSTRACT:
The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and modulate the activities of other polypeptides such as the class of peroxisome proliferators-activated receptors (PPARs) and γ-secretase. Also provided are methods of using the derivatives to treat pathological disorders.
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patent: WO02028831 (2002-11-01), None
Bahner et al.Anticancer compounds. Further analogs of 1-( 4-Dimethulaminobenzylidene)indene. Journal of Medicinal Chemistry, vol. 16, No. 4, (1973), pp. 421-425.
Touhey et al.Structure-activity relationship of indomethacin analogues for MRP-1, COX-1 and COX-2 inhibition identification of novel chemotherapeutic drug resistance modulators. European Journal of Cancer, vol. 38, No. 12, (2002), pp. 1661-1670.
Felts Andrew S.
Ji Chuan
Marnett Lawrence J.
Prusakiewicz Jeffery J.
Jenkins Wilson Taylor & Hunt, P.A.
Solola Taofiq A
Vanderbilt University
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