Indole-type derivatives as inhibitors of p38 kinase

Details Indole-type derivatives as inhibitors of p38 kinase Indole-type derivatives as inhibitors of p38 kinase

2007-05-22

2007-05-22

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S400000, C548S452000, C548S469000

Reexamination Certificate

active

10654840

ABSTRACT:
The invention is directed to methods to inhibit p38-α kinase using compounds comprising a phenyl or thienyl coupled through a piperidine or piperazine nucleus to an indole residue wherein the indole residue mandatorily has a substituent on the ring nitrogen which is an amino or substituted amino group.

REFERENCES:
patent: WO 96/40143 (1996-12-01), None
patent: WO 97/26252 (1997-07-01), None
patent: WO 98/06715 (1998-02-01), None
patent: WO 98/07425 (1998-02-01), None
patent: WO 99/61426 (1999-12-01), None
patent: WO 00/12074 (2000-03-01), None
patent: WO 00/59904 (2000-03-01), None
patent: WO 00/71535 (2000-11-01), None
patent: WO 02/42292 (2002-05-01), None
patent: WO 02/44168 (2002-06-01), None
Tetrahedron Lett. 23(37):3835-36 (1982).
Jiang et al., J Biol Chem 271:17920-26 (1996).
Kumar et al., Biochem Biophys Res Comm 235:533-538 (1997).
Stein et al., J Biol Chem 272:19509-17 (1997).
Li et al., Biochem Biophys Res Comm 228:334-40 (1996).
Wang et al., J Biol Chem 272:23668-74 (1997).
U.S. Appl. No. 60/395,693, filed Jun. 2002, Mavunkel et al.
U.S. Appl. No. 10/618,573, filed Jul. 2003, Mavunkel et al.

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