Indole inhibitors of 15-lipoxygenase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S419000, C548S465000, C548S492000

Reexamination Certificate

active

07429611

ABSTRACT:
The present invention provides indole inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

REFERENCES:
patent: 5612359 (1997-03-01), Murugesan
patent: 5712279 (1998-01-01), Biller et al.
patent: 5739135 (1998-04-01), Biller et al.
patent: 5760246 (1998-06-01), Biller et al.
patent: 6043265 (2000-03-01), Murugesan et al.
patent: 6548529 (2003-04-01), Robl et al.
patent: 6706720 (2004-03-01), Atwal et al.
patent: WO 00/01389 (2000-01-01), None
Misztal et al. “New Synthesis of 5-Nitro- and 5-Benzyloxytryptamine and their N-acylderivatives” Polish Journal of Pharmacology and Pharmacy, 1984, vol. 36, Iss 4, pp. 345-349.
Bleich, D. et al., “Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice”, The Journal of Clinical Investigation, vol. 103, No. 10, pp. 1431-1436 (1999).
Bocan, T. et al., “A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit”, Atherosclerosis, vol. 136, pp. 203-216 (1998).
Chu, L. et al., “Synthesis of 2-aryltryptamines with Palladium Catalyzed Cross-Coupling of 2-Bromotryptamines and Arylboronic Acids”, Tetrahedron Letters, vol. 38, No. 22, pp. 3871-3874 (1997).
Ducry, L. et al., “Synthesis of 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives and Evaluation of Their affinity for MHC Class-II Proteins”, Helvetica Chimica Acta, vol. 82, pp. 2432-2447 (1999).
Gan, Qing-Fen et al., “Defining the Arachidonic Acid Binding Site of Human 15-Lioxygenase”, The Journal of Biological Chemistry, vol. 271, No. 41, pp. 25412-25418 (1996).
Jiang, Zhen-Yue et al., “Lipid Hydroperoxide Measurement by Oxidation in Fe2+in the Presence of Xylenol Orange. Comparison with the TBA Assay and an Iodometric Method”, Lipids, vol. 26, No. 10, pp. 853-856 (1991).
Kelavkar, U. et al., “The Effect of 15-Lipoxygenase-1 Expression on Cancer Cells”, Current Urology Reports, vol. 3, pp. 207-214 (2002).
Rapoport, S. et al., “The Lipoxygenase of Reticulocytes”, Eur. J. Biochem., vol. 96, pp. 545-561 (1979).
Setty, B.N. et al., “15-Hydroxyeicosatetraenoic Acid-Mediated Potentiation of Thrombin-Induced Platelet Functions Occurs Via Enhanced Production of Phosphoinositide-Derived Second Messengers—sn-1,2-Diacylglycerol and linositol-1,4,5-Trisphosphate”, Blood, vol. 80, No. 11, pp. 2765-2773 (1992).
Soti, F. et al., “Preparation of 7-Methoxyryptamine”, Synthetic Communications, vol. 23, No. 12, pp. 1689-1698 (1993).
Sultana, C. et al., “Lipoxygenase Metabolites Induced Expression of Adhesion Molecules and Transendothelial Migration of Monocyte-Like HL-60 cells is Linked to Protein Kinase C Activation”, Journal of Cellular Physiology, vol. 167, pp. 477-487 (1996).
Takechi, H. et al., Intramolecular Photoreactions of Phthalimide-Alkene systems. Oxetane Formation ofN-(ω-Indol-3-ylalkyl)phthalimides1″ Chem.Pharm. Bull., vol. 36, No. 8, pp. 2853-2863 (1988).
Tisdale, Michael J., “Protein Loss in Cancer Cachexia” Science, vol. 289, pp. 2293-2294 (2000).
Weinstein, David et al., “Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase”, Bioorganic & Medicinal Chemistry Letters, vol. 15, pp. 1435-1440 (2005).

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