Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-03-10
1993-08-24
Higel, Floyd D.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546273, 548491, 548494, 548495, 548496, C07D20904, C07D21168, C07D25704, C07D41312
Patent
active
052390837
ABSTRACT:
The present invention provides Indole derivatives represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen or lower alkyl;
REFERENCES:
patent: 3109844 (1963-11-01), Perron et al.
patent: 3569011 (1971-02-01), Yamamoto et al.
patent: 4239902 (1980-12-01), Schnabel
patent: 4814463 (1989-03-01), Kim, I
patent: 4859692 (1989-08-01), Bernstein et al.
patent: 4902708 (1990-02-01), Kim, II
patent: 5041460 (1991-08-01), Matassa
patent: 5049679 (1991-09-01), Bernstein
patent: 5084455 (1992-01-01), Clemence et al.
patent: 5087701 (1992-02-01), Lubowitz et al.
patent: 5118700 (1992-06-01), Butler et al.
European Search Report of EP 92104088.7, Dated 14 Sep. 1992.
Patent Abstracts of Japan, vol. 12, No. 50 (C-476) [2897], Feb. 16, 1988, Abstract of Japanese Patent Document 62-198653.
Goodman and Gilman's, The Pharmacological Basis of Therapeutics, Eighth Edition, pp. 1427-1430, 1987.
Cecil, Textbook of Medicine, Wyngaarden, J. B., et al., pp. 1400-1401, 1422-1425 (1988).
The Testis, Scientific America, Inc., Section II, pp. 1-2, 8-9 and 12-15 (1991).
Encyclopedia of Human Biology, 4:243-244, 1987.
The Merck Index, Eleventh Edition, p. 4869 (Indole) (1989). I.
The Merck Index, Eleventh Edition, p. 7888 (Proscar) (1989). II.
Petrow, The Prostate, 9:344-361 (1986), "The Dihydrotestosterone (DHT) Hypothesis of Prostate Cancer and its Therapeutic Implications."
Rittmaster et al., Journal of Andrology, 10:259-262 (1989), "Effect of MK-906, a Specific 5.alpha.-reductase Inhibitor, on Serum Androgens and Androgen Conjugates in Normal Men."
Geller, I The Prostate Supplement, 2:95-104 (1989), "Pathogenesis and Medical Treatment of Benign Prostatic Hyperplasia."
Gormley et al., Journal of Clinical Endocinology and Metabolism, 70:1136-1141 (1990), "The Effects of Finasteride (MK-906), a 5.alpha.-Reductase Inhibitor, on Circulating Androgens in Male Volunteers."
Imperato-McGinley et al., Journal of Clinical Endocrinology and Metabolism, 70:777-782 (1990), "C.sub.19 and C.sub.21 5.beta./5.alpha. Metabolic . . . ".
Geller, II, Journal ofClinical Endocrinology and Metabolism, 71:1552-1555 (1990), "Effect of Finasteride . . . ".
Tenover, Endocrinol. Metab. Clin. North Amer., 20:893-909 (1991) (abstract only), "The Potential Medical Uses of Steroid 5alpha-reductase Inhibitors." Abstract only.
M. Bologna et al., Curr. Ther. Res. Clin. Exp., 51:799-813 (1992) (abstract only), "Antiandrogens and 5-alpha Reductase Inhibition of the Proliferation Rate . . . " Abstract only.
Ishii Akio
Kishibayashi Nobuyuki
Kumazawa Toshiaki
Obase Hiroyuki
Takami Hitoshi
Higel Floyd D.
Kyowa Hakko Kogyo Co. Ltd.
LandOfFree
Indole derivatives which inhibit steroid 5.alpha. reductase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indole derivatives which inhibit steroid 5.alpha. reductase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives which inhibit steroid 5.alpha. reductase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-830458