Indole derivatives which inhibit leukotriene biosynthesis

Details Indole derivatives which inhibit leukotriene biosynthesis Indole derivatives which inhibit leukotriene biosynthesis

1990-08-20

1992-03-10

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514415, 514418, 548484, 548493, 548494, 548495, 548496, 548504, 548505, 548507, A61K 31405, A61K 3140, C07D20912

Patent

active

050950312

ABSTRACT:
Substituted indolyl compounds of the formula ##STR1## are potent inhibitors of the lipoxygenase enzymes and are useful as agents for the treatment of allergies and inflammatory disease states.

REFERENCES:
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patent: 4464379 (1984-08-01), Betzing et al.
patent: 4654360 (1987-03-01), Greenhouse et al.
patent: 4814344 (1989-03-01), Humber et al.
patent: 4873259 (1989-10-01), Summers, Jr. et al.
S. Raucher et al., "Indole Alkaloid Synthesis Via Claissen Rearrangement", J. Am. Chem Soc. 103(9):2419-2412 (1981).
Kobayashi et al., "Indole Derivatives XII. Reaction of Indole-2-Carboxylic Acetic Acid Derivatives with Carbon Disulfide", Yakugaku Zasshi, 91(11):1164-1173 (1971) (in Japanese) the English language abstract from chemical abstracts (CA76:46033K (1972).

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