Indole derivatives useful as progesterone receptor modulators

Details Indole derivatives useful as progesterone receptor modulators Indole derivatives useful as progesterone receptor modulators

2007-01-16

2008-03-18

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S484000

Reexamination Certificate

active

07345084

ABSTRACT:
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

REFERENCES:
patent: 2002/0193415 (2002-12-01), LaColla et al.
patent: 1051179 (2005-09-01), None
patent: WO 99/43672 (1999-09-01), None
patent: WO 00/66555 (2000-11-01), None
patent: WO 02/083126 (2002-10-01), None
Fensome, A. et al.: “New Progesterone Receptor Antagonists: 3,3-Disubstituted-5-aryloxindoles”, Bioorganic & Medicinal Chem. Letters 12 (2002), pp. 3487-3490.
STN Search Report of WO 2001032621 (Nishimura et al.).

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