Indole derivatives, their production and use

Details Indole derivatives, their production and use Indole derivatives, their production and use

1992-10-19

1994-03-22

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 544336, 544333, 544238, 544212, 544 62, 544143, 544373, 5483647, 5483117, 5483121, 548113, 5483644, 5482664, C07D20918, A61K 31405

Patent

active

052964990

ABSTRACT:
An agent for inhibiting bone resorption comprising an indole derivative of the formula (I): ##STR1## wherein each ring of A and B is optionally substituted, R is a hydrogen atom, a lower alkyl group or an acyl group, and A is a hydroxymethyl group or an esterified or amidated carboxyl group; or its pharmaceutically acceptable salt and a pharmaceutically acceptable carrier, diluent or excipient.

REFERENCES:
patent: 4014883 (1977-03-01), Fryer et al.
Raisz, "Bone Resorption in Tissue Culture," J. Clin. Invest., vol. 44, No. 1, 1965, pp. 103-116.
European Search Report (1992).
Shigeho INABA et al., "Benzodiazepines. IV. A New Synthesis of 1-Diethylaminoethyl-substituted 1,4-Benzodiazepin-2-ones". Chem. Pharm. Bull., vol. 19, No. 2, pp. 263-272 (1971).
Gordon N. Walker et al., "Novel Syntheses of 1,4-Benzodiazepines, Isoindolo[2,1-d][1,4]benzodiazepines, Isoindolo[1,2-a][benzazepines, and etc." J. Org. Chem., vol. 37, No. 24, pp. 3755-3770 (1972).
Armin Walser et al., "The Synthesis and Transformations of Some 3-Chloro- and 3-Nitroindolenines", J. Org. Chem., vol. 38, No. 18, pp. 3077-3084 (1973).

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