Indole derivatives, preparation processes and medicinal products

Details Indole derivatives, preparation processes and medicinal products Indole derivatives, preparation processes and medicinal products

1992-03-20

1993-06-15

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514339, 514415, 544319, 546273, 548504, 548510, A61K 31505, A61K 31405, C07D23902, C07D20916

Patent

active

052198596

ABSTRACT:
The invention relates to indole derivatives of formula 1, ##STR1## in which: R.sub.1 and R.sub.2 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl, pyridylmethyl or phenyl, optionally substituted,
R.sub.3 and R.sub.4 represent H, halogen, alkyl, alkoxy, alkylthio, CF.sub.3, NO.sub.2, N-alkylamino or N,N-dialkylamino, benzyl or phenyl, optionally substituted,
R.sub.5 represents H, alkyl, cycloalkyl or optionally substituted benzyl,
R.sub.6 denotes an alkyl, phenyl or heterocyclic radical, optionally substituted,
Z denotes the bivalent radicals --(CH.sub.2).sub.n --C(R.sub.7 R.sub.8)--(CH.sub.2).sub.p --, --CH=CH--C(R.sub.7 R.sub.8)-- in which n=0--2, p=0--2 and n+p.ltoreq.2, R.sub.7 and R.sub.8 represent H, alkyl, alkenyl, cycloalkyl, N-alkylamino, N,N-dialkylamino, N-alkylamino- or N,N-dialkylaminoalkyl, benzyl or phenyl, where appropriate substituted, or together form polymethylene or oxa-, thia- or azapolymethylene chains,

REFERENCES:
CA 115 (13): 135908r Preparation of . . . 5-lipoxygenase inhibitors. Brooks et al., p. 963, 1991.
CA 115(23): 256019K Preparation of . . . immunotherapeutic agents, Schultz et al., p. 848, 1991.
CA 115 (23): 256179n Preparation of . . . LTD.sub.4 antagonists, Huang et al., p. 867, 1991,

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