Indole derivatives having antitumor activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C548S455000

Reexamination Certificate

active

08053460

ABSTRACT:
Indole derivatives of Formula (I+A) having antitumor and chemosensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumors.

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Boettcher, H. et al.: “Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1-pyridylalkyl) indoles. A novel conformational model to explain structure-activity relationship.” J. Med. Chem. vol. 35, No. 22, 1992, pp. 4020-4026.
Tokmakov, G.P. et al: “Interaction of 3,4-dihydro-2H-thiopyan with phenylhydrazines. Synthesis of homothiotrypophols” Database CA Chemical Abstracts Service, Columbus, Ohio, US, (2005).
Kayumov, V. et al.: Indole derivatives. LXXXIV. Hydroxamic acids of teh indole series. Database CA Chemical Abstracts Service, Columbus, Ohio, US, (2005).

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